学习工作经历：

2019年9月至2024年6月：武汉大学，生物学，理学博士学位

研究课题：

1.Pygo2/EZH2/miR-31调节回路在脑胶质瘤发展进程中的作用机制研究（81602448）参与

2.STYK1通过ATG14L-Beclin1-VPS34复合体促进细胞自噬及其对胰腺癌发展进程的调控研究 （31871420）参与

3.LncRNA-PVT1通过Pygo2调控细胞自噬在胰腺癌吉西他滨耐药中的分子机制研究 （31701228）参与

4.对组学探索RNA结合蛋白RBM22在5q-综合症中的功能与机制（32371356）参与

研究成果：

1.Du, X.#,Qin, W#., Yang, C. et al. RBM22 regulates RNA polymerase II 5′ pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5.Genome Biol25, 102 (2024)

2.Zhou C.#, Cheng H.#,Qin W.#, Zhang Y, Xiong H, Yang J, Huang H, Wang Y, Chen XZ, Tang J. Pygopus2 inhibits the efficacy of paclitaxel-induced apoptosis and induces multidrug resistance in human glioma cells.Oncotarget. 2017 Apr 25;8(17)

3.C. Zhou, C. Yi, Y. Yi, W.Qin, Y. Yan, X. Dong, X. Zhang,Y. Huang, R. Zhang, J. Wei, D. Ali, M. Michalak, X-Z. Chen, J. Tang*. (2020) LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.Mol Cancer,19,118:1-24.

4.Wang Q, Groenendyk J, Paskevicius T,Qin W, Kor KC, Liu Y, Hiess F, Knollmann BC, Chen SRW, Tang J, Chen XZ, Agellon LB, Michalak M. Two pools of IRE1α in cardiac and skeletal muscle cells.FASEB J. 2019

5.Wang Q, Paskevicius T, Filbert A,Qin W, Kim HJ, Chen XZ, Tang J, Dacks JB, Agellon LB, Michalak M. Phylogenetic and biochemical analysis of calsequestrin structure and association of its variants with cardiac disorders.Sci Rep. 2020

专利（第一发明人）：ZL 2017 1 0129492.8 ZL 2017 1 0129373.2