个人简介：

肖帅，硕士生导师，湖北工业大学生物医药研究院/生命科学与健康学院讲师。武汉市“武汉英才”（优秀青年人才）入选者。河南驻马店人，中共党员。2021年12月毕业于武汉大学微生物学专业，理学博士学位。近年来主要研究方向为细胞周期调控与细胞增殖异常，对肺癌的发生、转移及耐药的分子机制进行深入探究。近五年以第一作者/共同作者发表10余篇SCI论文。主持/参与国家自然科学基金、国家重点研发计划、湖北省自然科学基金等多个科研项目。中国细胞生物学学会(CSCB)、中国生物物理学会(BSC)会员、中国病理生理学会（CAP）、湖北省细胞生物学学会及湖北省生物工程学会会员。

研究课题：

2024年湖北省自然科学基金项目，2024AFB218，2024.03-2026.03，主持

2022年“武汉英才”优秀青年人才项目，2023.01-2025.12，主持

2022年湖北工业大学人才引进科研项目，XJ2022003901，2022.12-2024.12，主持

2023年国家重点研发计划项目，2023YFC2507900，2022.11-2027.11，项目骨干

2023年国家自然科学基金面上项目，82370715，2024.01-2027.12，项目骨干

2022年湖北省科技厅-国际科技合作项目，2022EHB038，2022.10-2024.9，参与

2022年武汉市曙光计划项目，2022010801020272，2022.06-2024.07，参与

2020年湖北省重点研发计划项目，2020BCB044，2020/09-2022/07，参与

研究成果：

1. Xiao S, Yu YP, Liao M, Song DD, Xu XZ, Tian LL, Rui Zhang R, Lyu H, Guo D, Zhang Q, Chen XZ, Zhou CF, Tang JF. Post-Translational Modification of p62: Roles and Regulations in Autophagy. Cells, 2025,14(13), 1016.1.

2. Xiao S, Tian LL, Liao M, Song DD, Xu XZ, Yu YP, Rui Zhang R, Lyu H, Chen XZ, Qi Zhang, Zhou CF, Tang JF. Role of Ubiquitin-regulated EMT in Cancer Metastasis and Chemoresistance. Int J Bio Sci, 2025.

3. Xiao S, Xu XZ, Liao M, Song DD, Zhou CF, Tang JF. Potential risk of HDAC inhibitors in cancer therapeutics and feasible combination medication strategies. World J Clin Oncol, 2025.

4. Xiao S, Qin DM, Hou XY, Tian LL, Yu YP, Zhang R, Lyu H, Guo D, Chen XZ, Zhou C, Tang JF. Cellular senescence: a double-edged sword in cancer therapy. Front Oncol. 2023. 13:1189015.

5. Xiao S, Hu D, Gao Y, Ai Y, Luo S, Chen S, Wang B, Zhou L, Dong Y, Wang Y. Safety assessment of subtilisin QK in rats. BMC Pharmacol Toxicol. 2021; 22(1):38-49.

6. Xiao S, Dong Y, Hu K, Hu D, Zhou L, Wang Y. Acute and Subchronic Toxicities and Safety Pharmacology Studies of a Bacillus Subtilisin in Dogs. Biol Pharm Bull. 2021; 44(2):211-218.

7. Shi M, Zhang R, Lyu H, Xiao S, Guo D, Zhang Q, Chen XZ, Tang J, Zhou C. Long non-coding RNAs: Emerging regulators of invasion and metastasis in pancreatic cancer. J Adv Res. 2025, 9: S2090-1232(25)00073-6.

8. Zhou C, Dong X, Li S, Xi Y, Liu Y, Qian X, Song Z, Zhou L, Zhang R, Lyu H, Xiao S, Guo D, Zhang Q, Liu W, Xiong Y, Wang Z, Yan C, Zhang Z, Zhu H, Chen XZ, Song Z, Tang J. Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation. STTT. 2025 Jun 30;10(1):205.

9. Zhang R, Zhang X, Bai H, Cheng Q, Yao X, Li S, Torraca V, Yan C, Dong X, Miao S, Hu X, Yu Y, Wu Y, Tan H, Chen X, Liu S, Lyu H, Xiao S, Guo D, Zhang Q, Chen XZ, Song Z, Zhou C, Tang J. DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation. Nat Commun. 2025 Jul 1;16(1):5826.

10. Zhang R, Vincenzo Torraca, Lyu H, Xiao S, Guo D, Zhou C*, Tang J*. RUNDC1 negatively mediates the fusion of autophagosomes with lysosomes via regulating SNARE complex assembly. Autophagy. 2024. 20(2):454-456.

11. Zhang R, Yang Y, He C, Zhang X, Torraca V, Wang S, Liu N, Yang J, Liu S, Yuan J, Gou D, Li S, Dong X, Xie Y, He J, Bai H, Hu M, Liao Z, Huang Y, Lyu H, Xiao S, Guo D, Ali DW, Michalak M, Ma C, Chen XZ, Tang J, Zhou C. RUNDC1 inhibits autolysosome formation and survival of zebrafish via clasping ATG14-STX17-SNAP29 complex. Cell Death Differ. 2023, 30(10):2231-2248.

12. Yuan W, Zhang R, Lyu H, Xiao S, Guo D, Zhang Q, Ali DW, Michalak M, Chen XZ, Zhou C, Tang J. Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies. Cell Death Discov. 2024 Jul 17;10(1):327.

13. Zhang X, Wu N, Huang H, Li S, Liu S, Zhang R, Huang Y, Lyu H, Xiao S, Ali DW, Marek M, Chen XZ, and Zhou C. Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity, Oncogene, 2023, 42(32):2439-2455.